Project 1

Identification of functional dependencies to prevent MPN disease progression

Project 2

Longitudinal comprehensive transcriptome analyses to unravel disease persistence and evolution in MPN

Project 3

A bad seed in bad soil: understanding the effect of NFE2 levels on HSC cell fate and its modification by the BM niche

Project 4

Targeting aberrant cell signaling to eradicate persistent MPN cells

Project 5

Targeting Kindlin-3-mediated integrin activation and signaling to target persistence in MPN

Project 6

Characterizing the impact of inflammatory signaling on MPN disease persistence

Project 7

Targeting immune escape mechanisms to eliminate persisting MPN cells

Project 8

Targeting aberrant chromatin states during disease persistence and progression in MPN

Project 9

Identification of niche factors and inflammatory cytokines driving disease progression in MPN

Project Z

Interoperable standardized and harmonized TARGET MPN data platform