Over the last decades, biomedical data continue to grow in scale, diversity, and complexity especially as the costs of the generation, access, storage, distribution, and analysis of data are undergoing a rapid evolution. These changes present researchers and clinicians with several challenges in managing these data and designing appropriate data platforms.

The key now is to use knowledge from previously published work to establish an interoperable standardized and harmonized TARGET-MPN data platform for optimal use within the consortium. In the end, this will also allow for secondary use of the data, providing substantial opportunities for global health intelligence and research in the future.

In brief, this project will provide the platform for data management and data sharing following the FAIR (findable, accessible, interoperable, and reusable) principles, i.e. a multi-omics data repository integrating metadata and processing standards from the German Human Genome-Phenome Archive (GHGA), GenomDE, GEnomics Reporting and the molecular-genetics module developed by the MII.

Our interoperable data platform will include data harmonization and standardization, thereby providing a valuable resource not only for consortium members, but also for the research community in general as interoperable interfaces as well as data harmonization and standardization will allow the connection to other data-sharing networks.

Overall, the Z-project will establish a scalable, secure, interoperable standardized and harmonized data platform for the TARGET-MPN consortium to allow for integrative data analysis. The general aims of this project are:

 To develop a Data Management Plan.

 To implement FAIR principles – definition of common data elements.

To facilitate the standardization and harmonization process.

 To provide data security.